Low-Dose Naltrexone For Fibromyalgia

A scientist working on Low-Dose Naltrexone For Fibromyalgia
Adam Foster

This article is part of our comprehensive guide to living with fibromyalgia.

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References:

  1. ‌Australian Journal of General Practice. (2023). Low dose naltrexone in the treatment of fibromyalgia. [online] Available at: https://www1.racgp.org.au/ajgp/2023/april/low-dose-naltrexone-in-the-treatment-of-fibromyalg.
  1. Andersen, M.L., Araujo, P., Frange, C. and Tufik, S. (2018). Sleep Disturbance and Pain. Chest, 154(5), pp.1249–1259. doi:https://doi.org/10.1016/j.chest.2018.07.019.
  1. Gerhart, J.I., Burns, J.W., Post, K.M., Smith, D.A., Porter, L.S., Burgess, H.J., Schuster, E., Buvanendran, A., Fras, A.M. and Keefe, F.J. (2016). Relationships Between Sleep Quality and Pain-Related Factors for People with Chronic Low Back Pain: Tests of Reciprocal and Time of Day Effects. Annals of Behavioral Medicine, [online] 51(3), pp.365–375. doi:https://doi.org/10.1007/s12160-016-9860-2.
  1. Younger, J. and Mackey, S. (2009). Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study. Pain Medicine, 10(4), pp.663–672. doi:https://doi.org/10.1111/j.1526-4637.2009.00613.x.
  1. Clinicaltrials.gov. (2025). Available at: https://clinicaltrials.gov/study/NCT04270877 
  1. ‌Driver, C.N. and D’Souza, R.S. (2023). Efficacy of Low-Dose Naltrexone and Predictors of Treatment Success or Discontinuation in Fibromyalgia and Other Chronic Pain Conditions: A Fourteen-Year, Enterprise-Wide Retrospective Analysis. Biomedicines, 11(4), p.1087. doi:https://doi.org/10.3390/biomedicines11041087.
  1. Bruun, K.D., Amris, K., Vaegter, H.B., Blichfeldt-Eckhardt, M.R., Holsgaard-Larsen, A., Christensen, R. and Toft, P. (2021). Low-dose naltrexone for the treatment of fibromyalgia: protocol for a double-blind, randomized, placebo-controlled trial. Trials, 22(1). doi:https://doi.org/10.1186/s13063-021-05776-7.

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